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  • International Name: RELIEF
  • Pharmacological group: Used in proctology
  • Manufacturer: Famar SA Greece / Bayer K.K.
  • Issuance form: Group III over-the-counter
  • Medicinal form: Rectal ointment

Yellow ointment without foreign matter, with a faint characteristic odor.

Active substances: Phenylephrine hydrochloride 2.5 mg / g

Excipients: mineral oil, Vaseline, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), anhydrous lanonyl, benzoic acid (E210), corn oil, glycerol, lanolin E 58, lanolin Wax, purified water.

Pharmacotherapeutic group
Other remedies for the treatment of hemorrhoids and anal fissures for external use. ATC code: C05AX.

Pharmacological properties
Phenylephrine hydrochloride is an alpha-adrenergic agent that exhibits a local vasoconstrictive effect that reduces eqsudaci, tissue swelling, and itching in the anorectal area.

Receiving testimonials
As an asymptomatic remedy for hemorrhoids, back body fractures, perianal itching.

Method of use and dosage
The drug is used after hygienic procedures. Remove the applicator from the protective cap, attach the applicator to the tube, and expel some of the ointment to lubricate the applicator. With the help of the applicator, the ointment is gently applied to the affected areas, from the outside or the back of the body, up to 4 times a day (in the morning, before bedtime and after all bowel movements). After each use, wash the applicator thoroughly and place it in a protective tray. In children under 12 years - with a doctor's prescription.

The dose used for self-medication of hemorrhoids in adults and children under 12 years should not exceed 2 mg of phenylephrine hydrochloride per day (1 g of ointment contains 2.5 mg of phenylephrine hydrochloride). It is not recommended to exceed this dose without a doctor's recommendation.

Side effects
The following side effects are possible:

From the cardiovascular system: reflex bradycardia, arrhythmia, elevated blood pressure.

From the immune system: Hypersensitivity reactions, including cross-reactions in the case of allergic reactions to other sympathomimetic agents, which may be manifested by skin rash, itching, angioedema, contact dermatitis.

On the part of the nervous system: dizziness, neurosis, headache, tremor, insomnia, the feeling of anxiety, possible development of seizures.

From the skin and subcutaneous tissues: contact dermatitis, hyperemia, skin rash, itching, swelling, pain, burning.

If you get any side effects, talk to your doctor. This recommendation applies in case of any adverse reactions, including those not described in the leaflet. You can also report adverse drug reactions in a database of adverse reactions (actions), including information on the effectiveness of medications. By providing information about adverse reactions, you are helping to get more information about the safety of the drug.

Hypersensitivity to the ingredients of the drug, severe arterial hypertension, tachycardic disorders of the heart rhythm, decompensated heart failure, the permeability of the heart, acute renal and/or hepatic insufficiency, thyrotoxicosis, acute pancreatitis, thromboembolism, thromboembolism, thromboembolism ) Concomitant administration of concomitant administration for 14 days after discontinuation of inhibitor therapy.

Significance of hypercoagulability may occur in the event of a significant excess of the recommended daily dose.

Overdose may include the following disorders: Arterial hypertension, pain and discomfort in the heart area, palpitations, respiratory disorders, non-cardiogenic pulmonary edema, agitation, convulsions, sleep disturbances, anxiety, irritability, psychosis, hallucinations, nausea, nausea, general Disorders of secretion, redness of the face, cold sensation in the extremities, paresthesia, hyperglycemia, hypokalemia, decreased blood supply to vital organs, which can lead to deterioration of blood supply to the kidneys, metabolic acidosis, increased work of the heart due to generalized peripherals. Treatment is symptomatic.

Security measures
Patients with arterial hypertension, cardiovascular disease, thyroid disease, closed-angle glaucoma, diabetes mellitus, liver disease, pancreatitis, urinary incontinence (eg, in case of hyperplasia of the present gland, may be used in case of conjunctivitis).

Prior to prescribing the drug, the doctor should clarify the history of allergies, including allergic reactions to other sympathomimetic drugs.

In case of heavy bleeding from the back of the body or if there is no therapeutic effect, be sure to consult a doctor.

Interaction with other medicinal products
The drug should not be used concomitantly with other vasoconstrictors (no matter the route of administration of these drugs), as well as with antihypertensive drugs (beta-adrenergic blockers). Concomitant use of phenylephrine and beta-blockers may lead to hypertension and overt bradycardia, which may lead to heart block.

Caution is prescribed in the treatment of thyroid hormones with drugs that affect the conduction of the heart (cardiac glycosides, antiarrhythmics). Concomitant use with drugs that induce potassium excretion (eg, furosemide-type diuretics) may increase hypokalemia and decrease susceptibility to vasopressor drugs such as phenylephrine.

Concomitant use of phenylephrine with other symptomatic agents may lead to additional stimulation of the central system, accompanied by irritability, irritability, insomnia, possible development of convulsive seizures.

The use of the drug Relief is not recommended when taking the inhibitor MAO or within 14 days after discontinuation of this drug.

Use during pregnancy and lactation
The drug is not recommended for women with obstetrics and breastfeeding.

Caution is advised against possible side effects from the nervous system.

Storage conditions
At a temperature not exceeding 25 ° C, out of reach for children.

Shelf life: 2 years. Do not use it after the expiration date indicated on the package.

Packing : 28.4 g tube. The tube with the applicator and the sheet insert is placed in a cardboard box.

Conditions of release: Out of prescription.