Ses Bacteriophage Annotation

Composition:

SES bacteriophage is a sterile filtrate of phage lysates active to:

• Staphylococcus (S. aureus, S.epidermidis) titter no less than 10ml.
• Streptococcus (S.pyogenes, S. sanguis, S.salivarius, S. agalactiae) titter no less than 10 ml.

• Different types of Escherichia coli titter no less than 10 ml 

Inactive Ingredients: Bacteriological growth medium, standard sodium saline, Chinazolin as a conservator.

Description: Preparation is a transparent liquid, with yellow to light brown color.

Pharmacological specifications:

Pharmaco-therapeutically group: Specific antibacterial solution.

Pharmacological actions: SES bacteriophage leads to specific lysis of bacteria belonging to Staphylococci, Streptococci, and Enteropathogenic E.coli of different serovars.

Prescription: SES bacteriophage can be used for therapeutic and prophylactic purposes in pyo-inflammatory and enteric infections caused by the above-mentioned microorganisms.

Indications: Otolaryngologic diseases, Otitis, tonsillitis, laryngitis, rhinitis, tracheitis, bronchitis, pneumonia, pleurisy. Skin infections: furunculosis, carbunculosis, deep infiltration and abscessing sycosis. Surgical diseases: Abscess, wound infections, mastitis, osteomyelitis, phlegmon. Inflammation of oral cavity: stomatitis, gingivitis, pyelonephritis, endometritis. Enteric infections: gastroenterocolitis, cholecystitis, staphylococcal toxic infection, dysbacteriosis. Pyo- inflammatory disease in children (including newborns). Prevention of postoperative periods and hospital infection

Usage and dosage: Used for treatment of lesions locally (as tampon). and for injecting into the cavity (bladder, pleural and peritoneal cavity, nasal cavity, deep wounds, abscesses, uterus, and vagina). The preparation is also recommended for using by enemas and injecting through a tube and drainage. When applied locally, the treatment term does not exceed 3-8 days, 3 times a day. The amount of preparation to be applied is defined according to the size of the affected area, it varies from 50 to 200ml. Phage therapy can start only after cleaning the wound or cavity of the pus. In the case of cystitis and pyelitis, the phage can be applied by a catheter. In the case of cholecystitis 30 ml of phage is applied through the tube, once in 2 days. In the case of conjunctivitis, the phage is dropped in the eye 4-6 times a day 2-3 drops. In newborns with pyoderma, the phage is used with napkins, 2 times a day, Treatment lasts from 5 to 7 days. Before taking the phage per os taking 2-3% solution of baking soda is recommended.

Special warnings: Before using the ampoule / Vial should be well shaken, The contents should be transparent liquid without sediment. The preparation should not be used in case of ampoules/Vials damage or if the liquid inside is non-transparent! Do not store and use the drug after destroying the integrity of the ampoule / Vial!!!

Overdosing: During the usage of SES bacteriophage, overdosing symptoms have not been revealed.

Contradiction: Usage of SES bacteriophage does not have contradictions

Side effects: No side effects have been revealed during usage of SES bacteriophage

Usage together with other preparations: Preparation can be used in parallel or supplemental to other medications. Drinking alcohol during treatment with bacteriophages is not recommended.

Pregnancy and lactation: Preparation can be used during pregnancy and lactation period.

Developed by: G. Eliava Institute of bacteriophage, Microbiology and virology.