Fersisi Bacteriophage Annotation


Name of the pharmaceutical product (Patentable): Fersisi Bacteriophage


Fersisi bacteriophage is a sterile  filtrate of phage lysates to

  • Staphylococcus (S. aureus, S. epidermidis) titter no less than 10ml.
  • Streptococcus (S. pyogenes, S. sanguis, S. salivarius, S. agalactiae ) titter no less than 10ml.

Inactive ingredients Bacteriological growth medium, standard sodium saline. Chinazolin as a conservator.


Preparation is a transparent liquid, with yellow, to light brown color.

Pharmacological specifications:

Pharmaco-therapeutical group:

Specific antibacterial solution

Pharmacological actions:

Fersisi Bacteriophage leads to specific lysis of bacteria belonging to Staphylococci and Streptococci.


To be used with curative and prophylaxis aim in pyo-inflammatory and enteric infections caused by the above-mentioned microorganisms.


Otolaryngological diseases: inflammation of the middle ear, tonsillitis, laryngitis, rhinitis, tracheitis, bronchitis, pneumonia, pleurisy. 

Skin infections: furunculosis, carbunculosis, abscess, deep infiltration and abscessing sycosis. 

Surgical diseases: Abscess, wound infections, mastitis, osteomyelitis, phlegmon.

Inflammation of oral cavity: stomatitis, gingivitis, etc.

Eye diseases: bacterial conjunctivitis: Secondary infections with thermal burns.

Urogenital and gynecologic infections: urethritis, cystitis, pyelonephritis, endometritis.

Enteric infections: gastroenterocolitis,  cholecystitis, staphylococcal toxic infection, dysbacteriosis.

Pyo- inflammatory disease in children (including newborns) prevention of postoperative periods and hospital infection.

Usage and dosage:

The highest effect is achieved when preparation is used at the onset of the disease and introduced directly to the infection's focus.

FERSISI bacteriophage may be used per os and /or rectum.

  • Fersisi bacteriophage is used as a disinfecting agent for locally damaged areas by phage soaked bandage, as well as in liquid form in cavities (wound cavity, abdominal cavity, pleura, abscess cavity, nasal cavity, urinary bladder, uterus, vagina). The preparation can be used orally, and/or by catheter, or enema.
  • Phage for local use is applied three times daily, for 3-5 days. The quantity of phage is determined by the size of the damaged area.
  • For the treatment of abscesses, pleuritis and arthritis, as well as peritonitis, 50-200ml of bacteriophage is introduces into the cavity every other day.
  • In the case of cystitis and pyelonephritis, the phage is administered by catheter and/or orally.
  • For the treatment of deep pyoderma, the phage is used intradermally (0.1-0.5ml in 10 injections).
  • For conjunctivitis, the bacteriophage is introduced by pipet, 2-3 drops per eye4-6 times a day.
  • In the case of neonatal omphalitis and pyoderma, the bacteriophage is applied by a soaked bandage twice daily for 5-7 days.
  • For intestinal diseases and dysbacteriosis phage is administered per os/or per rectum. Per rectum Fersis- Bacteriophage is introduced by enema, after stool.

Recommended doses and FERSISI bacteriophage are as follows:

Age Per os/Per day Per rectum/Per day
Infants 0-6 months 5ml 1 times, 30 min before feeding 10 ml once a day
Kids 6-12 months 5ml 2 times, 30 min before feeding 10 ml once a day
kids 1-3 years 5ml 3 times, 1 hour before the meal 20 ml once a day
Children 3-8 years 10ml 2-3 times. 1 hour before the meal 30 ml once a day

Children older than 8 years, adults

20ml 2-3 times, 1 hour prior to the meal

 40 ml once a day

Treatment should continue for 6-10 days.

Before taking FERSISI bacteriophage, it is recommended to take a glass of basic mineral water (or 2-3% solution of baking soda).


There are no contraindications ever observed for FERSISI bacteriophage, The use of FERSISI bacteriophage does not exclude concomitant use of antibiotics, or any other medicine.

Special Precautions

Before use, the ampule must be shaken, The liquid must be clear, without sediment.

If the ampoule is damaged, or if the liquid is cloudy, the preparation should not be used.

The preparation should be used immediately after the ampule or flask has been opened. Once opened it should not be saved for later use.

Packaging and Storage Conditions

The preparation is presented in 5 ml ampoules, Storage temperature +2 - +8 C Expiration - 1 Year

Distributed without prescription

Developed by: G. Eliava Institute of bacteriophage, Microbiology and virology.